Key result
Intravenous pentamidine administration was associated with the occurrence of dramatic T wave alternans, brief bouts of torsades de pointes, and QT prolongation.
Intravenous pentamidine is associated with potentially fatal arrhythmias including T wave alternans and torsades de pointes, warranting ECG monitoring.
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May prompt ECG monitoring during IV pentamidine; leaves open systematic safety evaluation in larger cohorts.
We report the case of a patient in whom dramatic T wave alternans with brief bouts of torsades de pointes and QT prolongation occurred in association with intravenously administered pentamidine. This ECG marker of a potentially fatal side effect, although uncommon, should be looked for in patients requiring the use of this drug.
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Kroll et al. (2002) studied this question. Intravenous pentamidine administration was associated with the occurrence of dramatic T wave alternans, brief bouts of torsades de pointes, and QT prolongation.
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