Key result
Pentamidine isethionate treatment was associated with torsade de pointes after an average of 10 days, a complication that may be synergistically induced by hypomagnesemia.
Why the study?
Does pentamidine isethionate treatment cause ventricular tachyarrhythmias such as torsade de pointes?
Case Report (n=2)
Does pentamidine isethionate treatment cause ventricular tachyarrhythmias such as torsade de pointes?
Pentamidine treatment can induce torsade de pointes, which may be exacerbated by hypomagnesemia and warrants early magnesium supplementation when QTc prolongation is observed.
Answers are grounded in this paper and cite their sources.
Suggests QTc monitoring and magnesium repletion during pentamidine; case report leaves open prospective confirmation of preventive benefit.
Pentamidine isethionate has been associated with ventricular tachyarrhythmias, including torsade de pointes. This article reports two cases of this complication and reviews all reported cases to date. Pentamidine-induced torsade de pointes may be related to serum magnesium levels and hypomagnesemia may synergistically induce torsade. Torsade de pointes occurred after an average of 10 days of treatment with pentamidine. In these patients, no other acute side effects of pentamidine were observed. Torsade de pointes can be treated when recognized early, possibly without discontinuation of pentamidine. When QTc interval prolongation is observed, early magnesium supplementation is advocated.
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Mani et al. (1993) conducted a case report in Pentamidine-induced torsade de pointes (n=2). Pentamidine isethionate was evaluated on Torsade de pointes. Pentamidine isethionate treatment was associated with torsade de pointes after an average of 10 days, a complication that may be synergistically induced by hypomagnesemia.
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