Key result
Balanites aegyptiaca extract reduced Doxorubicin-induced cardiotoxicity, evidenced by significant reductions in serum LDH, CK-MB, inflammatory cytokines, and oxidative stress markers.
Why the study?
The use of Doxorubicin in treating different tumours is restricted by its cardiotoxicity.
Does Balanites aegyptiaca extract prevent Doxorubicin-induced cardiotoxicity in male rats?
Does Balanites aegyptiaca extract prevent Doxorubicin-induced cardiotoxicity in male rats?
Balanites aegyptiaca extract demonstrates potential cardioprotective and antioxidant effects against doxorubicin-induced cardiotoxicity in a rat model.
Background and Objective: The use of Doxorubicin® (Doxo) in the treatment of different tumours is restricted due to its cardiotoxicity. The objective of this study was to determine the protective effect of Balanites aegyptiaca extract against cardiotoxicity induced by Doxorubicin® in male rats. Materials and Methods: Adult male rats (140-160) were parted into 6 groups (10 animals each) as follows: Group (1) Normal rats the control, group (2) Rats were administered BAE (200 mg kg1) orally for 4 weeks, group (3) Rats were treated IP with the anticancer drug (Doxorubicin®) at the dose of (0.5 mg kg1) for 4 weeks, group (4) Administrated orally with BAE in combination with Doxo injection for 4 weeks, group (5) Rats orally with BAE before intoxication with Doxo for 4 weeks and finally group (6) Animals post-administration of BAE for 4 weeks after intoxication with Doxo. After 4 weeks of injections. Results: Revealed that BAE succeeded to decline the Doxorubicin cardiotoxicity, this was evidenced by the significant reduction of serum LDH, CK-MB, total cholesterol, triglycerides, HDL, TNF-α, IL-1β and IL-6 as well as cardiac MDA and nitric oxide levels coupled with marked improvement in serum LDL, PON1 as well as cardiac GSH, SOD and CAT. Moreover, the BAE induced prominent regeneration of the cardiac muscle. Conclusion: Balanites aegyptiaca extract may be a promising cardio-protector against Doxorubicin® toxicity mediated through their antioxidant and radical scavenging activities.
No takes yet. Share an insight, caveat, or question.
Gomaa et al. (2022) studied Doxorubicin-induced cardiotoxicity (n=60). Balanites aegyptiaca extract vs. Doxorubicin alone and normal control was evaluated on Cardiotoxicity (serum LDH, CK-MB, lipids, cytokines, oxidative stress markers). Balanites aegyptiaca extract reduced Doxorubicin-induced cardiotoxicity, evidenced by significant reductions in serum LDH, CK-MB, inflammatory cytokines, and oxidative stress markers.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: