Key result
The deletion/deletion ACE polymorphism was associated with a nearly three-fold increased risk of venous thrombosis among African-American men (OR 2.8; 95% CI 1.2-6.2).
Why the study?
Are Factor V Leiden, MTHFR variant, and ACE insertion/deletion polymorphism associated with venous thrombosis in African Americans?
Population
278 African-American subjects attending clinics at an urban, public hospital in Atlanta, Georgia, in…
Comparison
Presence of Factor V Leiden mutation, MTHFR… vs Control subjects without venous thrombosis /…
Design
Case-control
Authors
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Requires replication before clinical consideration; leaves open ACE polymorphism role in venous thrombosis among African-American men.
Case-Control (n=278)
No
Are Factor V Leiden, MTHFR variant, and ACE insertion/deletion polymorphism associated with venous thrombosis in African Americans?
Odds Ratio: 1.5 (95% CI 0.9–2.6)
The D allele of the ACE gene may be associated with an increased risk of venous thrombosis specifically among African-American men.
Dilley et al. (1998) conducted a case-control in Venous thrombosis (n=278). Deletion/deletion ACE polymorphism vs. Other ACE genotypes was evaluated on Venous thrombosis (OR 1.5, 95% CI 0.9-2.6). The deletion/deletion ACE polymorphism was associated with a nearly three-fold increased risk of venous thrombosis among African-American men (OR 2.8; 95% CI 1.2-6.2).
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