Key result
The ACE gene insertion/deletion polymorphism (D allele) was not associated with an increased risk of venous thromboembolism (OR 0.97; 95% CI 0.81-1.16).
Why the study?
Does the ACE gene I/D polymorphism increase the risk of venous thromboembolism in unselected patients?
Population
517 unselected patients with venous thromboembolism and 478 blood donors (controls)
Comparison
Angiotensin-converting enzyme gene… vs Control group (blood donors)
Design
Case-control
Authors
Loading...
Does not support ACE I/D testing in VTE risk assessment; leaves open subgroup effects in future studies.
Case-Control (n=995)
Does the ACE gene I/D polymorphism increase the risk of venous thromboembolism in unselected patients?
Odds Ratio: 0.97 (95% CI 0.81–1.16)
Absolute Event Rate: 0.53% vs 0.54%
The ACE I/D polymorphism is not a significant genetic risk factor for venous thromboembolism in unselected patients.
Jackson et al. (2000) conducted a case-control in Venous thromboembolism (n=995). ACE gene insertion/deletion (I/D) polymorphism (D allele) vs. Controls (blood donors) was evaluated on Venous thromboembolism (OR 0.97, 95% CI 0.81-1.16). The ACE gene insertion/deletion polymorphism (D allele) was not associated with an increased risk of venous thromboembolism (OR 0.97; 95% CI 0.81-1.16).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: