Key result
The angiotensin converting-enzyme DD genotype was associated with a reduced risk of venous thromboembolism compared to ID and II genotypes (OR 0.35; 95% CI 0.16-0.78).
Why the study?
Does the ACE DD genotype affect the risk of venous thromboembolism in individuals from southern Brazil?
Population
142 individuals from the south of Brazil, comprising 71 patients with deep venous thrombosis and/or…
Comparison
Angiotensin converting-enzyme (ACE) DD genotype vs ACE ID or II genotypes
Design
Case-control
Authors
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ACE DD genotype may protect against VTE in southern Brazilians; challenges prior risk reports and leaves open need for validation.
Case-Control (n=142)
Does the ACE DD genotype affect the risk of venous thromboembolism in individuals from southern Brazil?
Odds Ratio: 0.35 (95% CI 0.16–0.78)
The ACE DD genotype appears to have a protective effect against venous thromboembolism in a southern Brazilian population, contrasting with some prior associations of increased risk.
Muñhoz et al. (2005) conducted a case-control in venous thromboembolism (n=142). Angiotensin converting-enzyme DD genotype vs. ID and II genotypes was evaluated on venous thromboembolism (OR 0.35, 95% CI 0.16-0.78). The angiotensin converting-enzyme DD genotype was associated with a reduced risk of venous thromboembolism compared to ID and II genotypes (OR 0.35; 95% CI 0.16-0.78).
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