Key result
The angiotensin-converting enzyme DD genotype was significantly associated with an increased risk of venous thromboembolism (OR 2.19; 95% CI 1.51-3.17; P<0.0001).
Why the study?
Does the ACE DD genotype increase the risk of venous thromboembolism?
Population
714 subjects, comprising 336 consecutive venous thromboembolism patients and 378 controls.
Comparison
Angiotensin-converting enzyme DD genotype and… vs Controls without venous thromboembolism / non-DD…
Design
Case-control
Authors
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The ACE DD genotype is an independent risk factor for venous thromboembolism and its recurrence, even in patients without traditional thrombophilic alterations.
Case-Control (n=714)
Does the ACE DD genotype increase the risk of venous thromboembolism?
Odds Ratio: 2.19 (95% CI 1.51–3.17)
p-value: p=<0.0001
The ACE DD genotype is an independent risk factor for venous thromboembolism and its recurrence, even in patients without traditional thrombophilic alterations.
Fatini et al. (2003) conducted a case-control in Venous thromboembolism (n=714). Angiotensin-converting enzyme (ACE) DD genotype vs. Controls (without VTE) was evaluated on Venous thromboembolism (OR 2.19, 95% CI 1.51-3.17, p=<0.0001). The angiotensin-converting enzyme DD genotype was significantly associated with an increased risk of venous thromboembolism (OR 2.19; 95% CI 1.51-3.17; P<0.0001).
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