Key result
Genomic analysis of group A equine rotaviruses showed a strong association between the VP7 genotype G3 and VP6 genotype I6, and between G14 and I2, suggesting co-evolution driven by protein interactions.
VP6 and VP7 interactions may drive the co-evolution and co-segregation of their respective gene segments in group A equine rotaviruses.
Hypothesis-generating for VP6-VP7 co-segregation in equine rotaviruses; larger studies needed to confirm evolutionary drivers.
Rotavirus virions are formed by three concentric protein layers that enclose the 11 dsRNA genome segments and the viral proteins VP1 and VP3. Interactions amongst the capsid proteins (VP2, VP6, VP7 and VP4) have been described to play a major role in viral fitness, whilst restricting the reassortment of the genomic segments during co-infection with different rotavirus strains. In this work we describe and characterize the linkage between VP6 and VP7 proteins based on structural and genomic analyses of group A rotavirus strains circulating in Argentinean horses. Strains with the VP7 genotype G3 showed a strong association with the VP6 genotype I6, whilst strains with G14 were associated with the I2 genotype. Most of the differences on the VP6 and VP7 proteins were observed in interactive regions between the two proteins, suggesting that VP6 : VP7 interactions may drive the co-evolution and co-segregation of their respective gene segments.
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Miño et al. (2016) studied Group A equine rotavirus. Genomic analysis of group A equine rotaviruses showed a strong association between the VP7 genotype G3 and VP6 genotype I6, and between G14 and I2, suggesting co-evolution driven by protein interactions.
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