Why the study?
African swine fever virus causes highly contagious swine disease and poses a severe socioeconomic threat, underscoring the urgent need for effective antiviral therapies.
Does cepharanthine inhibit African swine fever virus replication in porcine alveolar macrophages and infected pigs?
Population
ASFV-infected porcine alveolar macrophages and ASFV-infected pigs
Comparison
Cepharanthine treatment vs control or uninfected conditions
Design
In vitro compound screen and in vivo animal study
Key result
Cepharanthine provided partial protection against ASFV infection in pigs, increasing survival time from 9.67 days to 16.67 days.
Authors
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Cepharanthine shows no immediate role in ASFV control; hypothesis-generating in pigs and requires larger confirmatory studies.
Does cepharanthine inhibit African swine fever virus replication in porcine alveolar macrophages and infected pigs?
Absolute Event Rate: 16.67% vs 9.67%
Cepharanthine demonstrates potential antiviral activity against African swine fever virus by blocking viral entry, increasing survival time in infected pigs.
Qi et al. (2024) studied African swine fever virus (ASFV) infection. Cepharanthine (CEP) vs. Untreated control was evaluated on Survival time. Cepharanthine provided partial protection against ASFV infection in pigs, increasing survival time from 9.67 days to 16.67 days.