What question did this study set out to answer?

To characterize the clinical features, risk factors, and antimicrobial susceptibility profiles of endemic Burkholderia cepacia bacteraemia in hospitalized patients without cystic fibrosis.

January 1, 1999Scandinavian Journal of Infectious Diseases

Endemic Burkholderia cepacia Bacteraemia: Clinical Features and Antimicrobial Susceptibilities of Isolates

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To characterize the clinical features, risk factors, and antimicrobial susceptibility profiles of endemic Burkholderia cepacia bacteraemia in hospitalized patients without cystic fibrosis.
Conducted a matched case-control study over 3 years at China Medical College Hospital in Taiwan.
Matched 25 case-patients with B. cepacia bacteraemia to 25 control patients with nosocomial Escherichia coli bacteraemia.
Evaluated patient clinical histories, underlying conditions, and in vitro antimicrobial susceptibility profiles, using multivariate analysis to identify independent risk factors.
Multivariate analysis identified indwelling central venous catheter as the significant independent risk factor predisposing to B. cepacia bacteraemia (p = 0.025), with 11 cases meeting criteria for catheter-related bloodstream infection.
The overall case-fatality rate was 12% (3/25), with only 1 attributable death, showing no statistically significant difference in mortality compared with controls.
All isolates were susceptible (100%) to ceftazidime, piperacillin, and minocycline, while 84% were susceptible to imipenem.

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Implication

Case-control study reveals central venous catheters increase Burkholderia cepacia bacteraemia risk in hospitalized patients, highlighting the value of targeted antibiotics.

Cite This Study

Wen Yu (1999) studied this question.

synapsesocial.com/papers/6a9a3e32c83637f7e8fb55d5 https://doi.org/10.1080/00365549950163608

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Implication

Case-control study reveals central venous catheters increase Burkholderia cepacia bacteraemia risk in hospitalized patients, highlighting the value of targeted antibiotics.

Endemic Burkholderia cepacia Bacteraemia: Clinical Features and Antimicrobial Susceptibilities of Isolates

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Discussion

Implication

Cite This Study

Endemic Burkholderia cepacia Bacteraemia: Clinical Features and Antimicrobial Susceptibilities of Isolates

Key Points

Discussion

Implication

Cite This Study

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