Key result
Patients with acute posterior circulation ischemic strokes had significantly decreased aggregated blood flow volume in the vertebral arteries (105 ml/min) compared to healthy volunteers (141-143 ml/min).
Why the study?
The study aimed to determine normal cerebral blood flow volume and characterize its features in patients with acute posterior circulation ischemic strokes and vertebrobasilar insufficiency using color duplex sonography.
Does blood flow volume measured by duplex sonography differ between patients with posterior circulation ischemic strokes, vertebrobasilar insufficiency, and healthy volunteers?
Observational (n=190)
Does blood flow volume measured by duplex sonography differ between patients with posterior circulation ischemic strokes, vertebrobasilar insufficiency, and healthy volunteers?
Absolute Event Rate: 105% vs 142%
A significant decrease in vertebral artery blood flow volume measured by duplex sonography is specifically associated with acute posterior circulation ischemic strokes rather than vertebrobasilar insufficiency.
Decreased VA flow volume distinguishes PCIS from VBI; leaves open diagnostic role of routine duplex sonography in posterior circulation disease.
Objective: The aim of this study was to determine blood flow volume (BFV) in the normal state and its features in patients with acute posterior circulation ischemic strokes (PCIS) and vertebrobasilar insufficiency (VBI) using color duplex sonography (DS).Methods: The study included DS data from 96 patients with verified PCIS (66 men and 30 women, aged 64±13 years) and 29 adults with VBI (17 men and 12 women, aged 66±11 years). The control group consisted of 65 healthy male volunteers of different ages.Results: In asymptomatic healthy volunteers, there was a significant decrease in BFV in the internal carotid artery (ICA) with age (502 ml/min in young people, 465 ml/min in the older subgroup) with r S = −0.24 ( p = 0.05), and the aggregated BFV in the vertebral arteries (VAs) turned out to be almost constant (141–143 ml/min). In patients with VBI, the aggregated BFV in the VAs (144 ml/min) did not differ from that in healthy volunteers, but the BFV values in the ICAs were significantly lower (325 ml/min). In patients with PCIS, the aggregated BFV in the ICAs was also significantly lower (399 ml/min) than in the control group but did not significantly differ from that in patients with VBI. In patients with PCIS, there was a significant decrease in the aggregated BFV in the VAs (105 ml/min), which distinguished this group from other examined patients.Conclusions: A significant decrease the BFV in the VA was observed only in patients with PCIS and was associated with the presence of steno-occlusive diseases (SOD) more often in the left VA. Patients with VBI had the most pronounced decrease in BFV in the ICA.
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Vishnyakova et al. (2021) conducted an observational in Acute posterior circulation ischemic strokes (PCIS) and vertebrobasilar insufficiency (VBI) (n=190). Acute posterior circulation ischemic strokes (PCIS) vs. Healthy volunteers and patients with VBI was evaluated on Aggregated blood flow volume (BFV) in the vertebral arteries (VAs). Patients with acute posterior circulation ischemic strokes had significantly decreased aggregated blood flow volume in the vertebral arteries (105 ml/min) compared to healthy volunteers (141-143 ml/min).
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