Key result
Among 38 patients with Tako-tsubo cardiomyopathy and concurrent respiratory diseases, 100% had a favorable outcome and were discharged uneventfully.
Why the study?
Is there an association between respiratory diseases and the development of Tako-tsubo cardiomyopathy?
Systematic Review (n=38)
Is there an association between respiratory diseases and the development of Tako-tsubo cardiomyopathy?
Severe respiratory diseases and their treatments (e.g., high-dose β2-agonists) are likely triggers for Tako-tsubo cardiomyopathy, though short-term outcomes remain favorable.
Favorable short-term outcomes reassure on prognosis in Tako-tsubo cardiomyopathy with respiratory disease; leaves open causal association with triggers.
AIM: To investigate the possible association between Tako-tsubo cardiomyopathy (TTC)-a reversible clinical condition mimicking an acute myocardial infarction characterized by multifactorial pathophysiologic mechanisms- and respiratory system diseases. METHODS: We systematically searched PubMed and EMBASE medical information sources, to identify the different triggering causes, limiting our search to articles in English. The search keywords were: "tako-tsubo cardiomyopathy", "takotsubo", "takotsubo cardiomyopathy", "broken heart syndrome", "stress-induced cardiomyopathy", "apical ballooning syndrome", and "ampulla cardiomyopathy in combination with respiratory diseases, lung, pulmonary disease. For each kind of disease, we registered: author, year and country of study, patient sex, age, concurring situation, and outcome. RESULTS: Out of a total of 1725 articles found, we selected 37 papers reporting a total of 38 patients. As expected, most patients were women (81.6%), mean age was 65 ± 10 years. Outcome was favorable in 100% of cases, and all the patients have been discharged uneventfully in a few days. CONCLUSION: An association between respiratory diseases and TTC is likely to exist. Patients with severe respiratory diseases, due to the high dosages of β2-agonists used or to the need of invasive procedures, are highly exposed to the risk of developing TTC.
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Manfredini et al. (2014) conducted a systematic review in Tako-tsubo cardiomyopathy and respiratory diseases (n=38). Respiratory diseases was evaluated on Favorable outcome (discharged uneventfully). Among 38 patients with Tako-tsubo cardiomyopathy and concurrent respiratory diseases, 100% had a favorable outcome and were discharged uneventfully.
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