Key result
Perioperative administration of 80% oxygen did not significantly change intraoperative mean arterial pressure compared to 30% oxygen (MD -0.16 mmHg; 95% CI -1.83 to 1.51; p=0.85).
Why the study?
Supplemental oxygen increases peripheral vascular resistance and systemic blood pressure in several patient groups, but whether this occurs in anesthetized surgical patients was unknown.
Does 80% oxygen compared to 30% oxygen affect intraoperative blood pressure and heart rate in anesthetized patients undergoing major abdominal surgery?
RCT (n=258)
Does 80% oxygen compared to 30% oxygen affect intraoperative blood pressure and heart rate in anesthetized patients undergoing major abdominal surgery?
Mean Difference: -0.16 (95% CI -1.83–1.51)
Absolute Event Rate: 80% vs 81%
p-value: p=0.85
In anesthetized patients undergoing major abdominal surgery, administration of 80% versus 30% oxygen did not significantly affect intraoperative blood pressure or heart rate.
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High FiO2 does not increase intraoperative BP or lower HR in anesthetized surgical patients; challenges prior observations in awake or critically ill populations.
Reiterer et al. (2023) conducted an RCT in major abdominal surgery (n=258). 80% oxygen vs. 30% oxygen was evaluated on time-weighted average (TWA) of mean arterial pressure (MD -0.16 mmHg, 95% CI -1.83 to 1.51, p=0.85). Perioperative administration of 80% oxygen did not significantly change intraoperative mean arterial pressure compared to 30% oxygen (MD -0.16 mmHg; 95% CI -1.83 to 1.51; p=0.85).
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