Key result
Topical 1% indomethacin administered 30 minutes before surgery decreased prostaglandin E2 levels in the conjunctiva and cornea compared with placebo.
Why the study?
Does topical indomethacin reduce prostaglandin E2 levels in human cornea and conjunctiva?
RCT (n=36)
Masked
Does topical indomethacin reduce prostaglandin E2 levels in human cornea and conjunctiva?
Topical indomethacin significantly reduces prostaglandin E2 levels in human conjunctival and corneal tissues, suggesting potential as an anti-inflammatory agent for ocular disorders.
Answers are grounded in this paper and cite their sources.
Supports preoperative topical indomethacin to blunt ocular inflammation; extends animal data with first human RCT evidence of PGE2 reduction.
We studied the inhibitory effect of topical 1% indomethacin aqueous suspension on prostaglandin E2 in 20 conjunctivae extracted during cataract surgery and 16 corneas extracted during penetrating keratoplasty. Thirty minutes before each surgical procedure, indomethacin or placebo (0.9% sodium chloride solution) was instilled into the eye to be operated on in a masked fashion for conjunctiva and selectively for cornea. The excised corneal buttons and conjunctival tissue were homogenized and assayed for prostaglandin E2 concentration using radioimmunoassay. The levels of prostaglandin E2 in the conjunctiva significantly decreased (P less than .0033) after administration of indomethacin (203.7 +/- 219.5 pg/mg) compared with the placebo-treated tissues (849.8 +/- 564.1 pg/mg). The levels of prostaglandin E2 in the corneas significantly decreased (P less than .0157) after administration of indomethacin (522.5 +/- 570.2 pg in the cornea) compared with the placebo-treated tissues (1636.3 +/- 1344.1 pg in the cornea). Indomethacin may serve as a potent anti-inflammatory agent in conjunctival and corneal inflammatory disorders.
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Joseph Frucht‐Pery (1992) conducted an RCT in Cataract and corneal diseases requiring surgery (n=36). Topical 1% indomethacin aqueous suspension vs. Placebo (0.9% sodium chloride solution) was evaluated on Prostaglandin E2 concentration in conjunctiva (p=<.0033). Topical 1% indomethacin administered 30 minutes before surgery decreased prostaglandin E2 levels in the conjunctiva and cornea compared with placebo.
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