Key result
A high age-adjusted Charlson comorbidity index score was associated with a higher rate of 30-day Grade 3-5 adverse events following major pelvic surgery.
Why the study?
Does a high Age-adjusted Charlson Comorbidity Index (ACCI) predict Grade 3-5 adverse events in adult patients with pelvic malignancies undergoing major pelvic surgeries?
Observational (n=66)
Does a high Age-adjusted Charlson Comorbidity Index (ACCI) predict Grade 3-5 adverse events in adult patients with pelvic malignancies undergoing major pelvic surgeries?
The Age-adjusted Charlson Comorbidity Index has a high negative predictive value for 30-day severe adverse events in patients undergoing major pelvic oncological surgeries.
Answers are grounded in this paper and cite their sources.
ACCI was associated with higher severe perioperative complications in pelvic cancer surgery; extends CCI validation in this setting but remains hypothesis-generating.
Introduction: Charlson comorbidity index (CCI) is a validated tool enabling clinicians for prediction of adverse events posttherapy. In this study, we planned to estimate the predictive value of age-adjusted CCI (ACCI) in assessing the perioperative complication in oncological patients undergoing major pelvic surgeries. Methods: This was a single arm, prospective, observational study, in which adult patients with pelvic malignancies undergoing pelvic surgeries were selected. The relationship between the ACCI and Grade 3–5 adverse events were tested using Fisher's test. Results: The rate of Grade 3–5 adverse event rate was 16.7% (11 patients, n = 66). Among the whole cohort, 11 patients (16.7%) had high score on ACCI. The rate of Grade 3–5 adverse events was higher in the cohort of patients with high ACCI score (45.5% vs. 10.9%, P = 0.014). The sensitivity, specificity and negative and positive predictive values were 45.5%, 89.1%, 89.1%, and 45.5%, respectively. Conclusion: ACCI can predict for postsurgical adverse events. It has a high negative predictive value for nonoccurrence of adverse events.
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Dessai et al. (2018) conducted an observational in Pelvic malignancies (n=66). High age-adjusted Charlson comorbidity index (ACCI) score vs. Low ACCI score was evaluated on Grade 3-5 adverse events (p=0.014). A high age-adjusted Charlson comorbidity index score was associated with a higher rate of 30-day Grade 3-5 adverse events following major pelvic surgery.
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