Key result
Acetylcholine-induced relaxation involved NO alone in the aorta of normotensive rats, but was moderately depressed in hypertensive rats despite involvement of cyclooxygenase-1 vasodilator products.
Population
Lyon normotensive (LN) and Lyon hypertensive (LH) rats (aorta and small mesenteric arteries)
Comparison
Acetylcholine administration with and without… vs Lyon normotensive vs Lyon hypertensive rats…
Design
Preclinical
Authors
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Supports differential endothelial pathways in hypertensive rat aorta; hypothesis-generating and should not change clinical practice.
Endothelial function differs between conductance and resistance arteries and between normotensive and hypertensive rat strains, highlighting the varying roles of NO, EDHF, and cyclooxygenase products.
Freitas et al. (2003) studied Hypertension (animal model). Acetylcholine (ACh) and various inhibitors vs. Lyon normotensive vs Lyon hypertensive rats was evaluated on Endothelium-dependent vasorelaxation in aorta and small mesenteric arteries. Acetylcholine-induced relaxation involved NO alone in the aorta of normotensive rats, but was moderately depressed in hypertensive rats despite involvement of cyclooxygenase-1 vasodilator products.
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