Key result
In children with acute gastroenteritis in Northeastern Brazil, the prevalence of rotavirus was 12% (all G2P[4] genotype) and norovirus was 17% (predominantly GII.4).
Cross-Sectional (n=200)
No
In the post-monovalent rotavirus vaccination era in northeastern Brazil, RVA G2P[4] and multiple NoV genotypes were identified as circulating causes of acute gastroenteritis in children.
Surveillance for RVA G2P[4] and diverse NoV genotypes remains warranted post-RV1; leaves open whether these shifts alter pediatric AGE burden or vaccine strategy.
Group A rotaviruses (RVA) and noroviruses (NoV) are the leading cause of acute gastroenteritis (AGE) worldwide. Childhood diarrhea deaths and hospital admissions have declined since the introduction of the monovalent (G1P[8]) vaccine (Rotarix(®) [RV1]) in the National Immunization Program in Brazil in 2006. This study aims to investigate the epidemiological profile of NoV and RVA infections from children with AGE in the Northeastern region of Brazil in the post vaccine season. Two-hundred fecal samples collected from children up to 10 years old in Fortaleza, Ceará between 2008-2009 were screened for the presence of RVA and NoV. Positive samples were genotyped and sequenced. The RVA screening revealed 12% prevalence and all RVA strains belonged to G2P[4] genotype. Phylogenetic analysis based on the 11 RVA genome segments sequenced from eight samples revealed a DS-1-like genotype constellation: I2-R2-C2-M2-A2-N2-T2-E2-H2. For NoV screening, the prevalence observed was 17% and the following genotypes were detected: GII.4 (59%), GII.12 (17%), GII.6 (9%), GII.3 (6%), and GII.? (9%). At least four different NoVs genotypes and two RVA G2P[4] variants were identified circulating in the Northeastern region of Brazil. RVA phylogenetic analysis suggests that the RVA G2P[4] strains might have originated from intragenogroup reassortment events. Whether the genetic modifications observed in these contemporary G2P[4] RVA strains may impact the long-term effectiveness of the current vaccination programs remains to be explored. These data reinforce the importance of surveillance for monitoring the emergence of new strains of RVA and NoV and their impact on cases of acute gastroenteritis.
No takes yet. Share an insight, caveat, or question.
Sá et al. (2015) conducted a cross-sectional in Acute gastroenteritis (n=200). Rotavirus and norovirus infection was evaluated on Prevalence and genotypes of RVA and NoV. In children with acute gastroenteritis in Northeastern Brazil, the prevalence of rotavirus was 12% (all G2P[4] genotype) and norovirus was 17% (predominantly GII.4).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: