Key result
A single 600 mg oral dose of propafenone significantly decreased heart rate (-6%, P<0.05) and systolic blood pressure (-6%, P<0.05) during exercise in healthy males.
Why the study?
Does a single oral dose of 600 mg propafenone reduce heart rate and blood pressure during exercise in healthy males?
Population
12 healthy males
Comparison
Single oral dose of 600 mg propafenone vs Placebo
Design
RCT, Randomized cross-over protocol, Double-blind, placebo-controlled
Follow-up
4 hours following drug intake
Authors
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600 mg propafenone exerts clinically significant beta-blockade; confirms dual Class Ic/II effects and supports use in structural heart disease.
RCT (n=12)
Double-blind
Randomized cross-over
Does a single oral dose of 600 mg propafenone reduce heart rate and blood pressure during exercise in healthy males?
Effect estimate: -6%
p-value: p=< 0.05
A single 600 mg oral dose of propafenone demonstrates clinically significant beta-blocking (Class II) effects during exercise, suggesting its suitability for cardioversion of paroxysmal atrial fibrillation even in patients with structural heart disease.
Stoschitzky et al. (2015) conducted an RCT in Healthy (n=12). Propafenone vs. Placebo was evaluated on Heart rate at exercise (-6%, p=< 0.05). A single 600 mg oral dose of propafenone significantly decreased heart rate (-6%, P<0.05) and systolic blood pressure (-6%, P<0.05) during exercise in healthy males.
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