Key result
ELISA and FA detected specific IgM antibody to C burnetii for up to 17 weeks after symptom onset, compared to 10 weeks by CF-DG, offering a simpler method for confirming Q fever infection.
Why the study?
Does ELISA accurately detect and measure the persistence of specific IgM antibody to Coxiella burnetii compared to FA and CF-DG in patients with Q fever?
Population
130 serum samples from 38 patients with Q fever
Comparison
Enzyme-linked immunosorbent assay for specific… vs Indirect immunofluorescence test and complement…
Design
Other
Follow-up
up to 17 weeks
Authors
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ELISA may aid Q fever diagnosis without acute samples; leaves open validation in endocarditis cohorts.
Observational (n=38)
Does ELISA accurately detect and measure the persistence of specific IgM antibody to Coxiella burnetii compared to FA and CF-DG in patients with Q fever?
ELISA is an effective and less subjective method for detecting C burnetii-specific IgM to confirm Q fever infection when acute-phase samples are unavailable.
Field et al. (1983) conducted an observational in Q fever (n=38). Enzyme-linked immunosorbent assay (ELISA) vs. Indirect immunofluorescence (FA) and complement fixation (CF-DG) tests was evaluated on Detection and persistence of specific IgM antibody to C burnetii. ELISA and FA detected specific IgM antibody to C burnetii for up to 17 weeks after symptom onset, compared to 10 weeks by CF-DG, offering a simpler method for confirming Q fever infection.
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