Key result
Pig muscles express high proportions of fast MHC isoforms, including MHC-2B, with maximum shortening velocities higher than expected based on body size scaling.
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Caution against extrapolating pig muscle kinetics to human cardiac models; leaves open MHC isoform scaling in cardiovascular research.
Toniolo et al. (2004) studied this question. Myosin Heavy Chain (MHC) isoforms vs. Slow vs fast MHC isoforms was evaluated on Maximum shortening velocity (V(o)) and isometric tension (P(o)). Pig muscles express high proportions of fast MHC isoforms, including MHC-2B, with maximum shortening velocities higher than expected based on body size scaling.
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