Key result
In older adults with heart failure, high levels of physical activity (≥1000 MET-min/week) significantly reduced the risk of all-cause mortality compared to physical inactivity (HR 0.52).
Why the study?
Studies evaluating the results of exercise intensity in older patients with heart failure are scarce, especially within Asian populations.
Does physical activity reduce the risk of mortality and hospitalization in older Korean adults with heart failure?
Cohort (n=8,982)
Does physical activity reduce the risk of mortality and hospitalization in older Korean adults with heart failure?
Hazard Ratio: 0.52 (95% CI 0.41–0.67)
Absolute Event Rate: 2.4% vs 6.7%
p-value: p=<0.001
In older Asian adults with heart failure, even low levels of physical activity (1-499 MET-min/week) are associated with a reduced risk of all-cause mortality, with greater benefits seen at higher activity levels.
May support activity counseling in older HF patients; extends evidence to Asian cohorts but leaves causality open.
Background: Regular exercise improves the functional ability and quality of life of patients with heart failure (HF). However, studies on the results of intensity of exercise in the older population are scarce, especially in the Asian population. Method and Results: A total of 8982 older people (age ≥65 years) with HF were selected from the Korean National Health Insurance Service-Senior database (2005–2012). Participants were stratified according to the levels of physical activity per week as follows: (1) inactive group; (2) insufficiently active group: 1–499 metabolic equivalent task minutes (MET-min)/week; (3) active group: 500–999 MET-min/week; and (4) highly active group: ≥1000 MET-min/week. During a median follow-up period of 3.2 years, the incidence and risk of mortality were reduced in the insufficiently active (6.7 vs. 4.2 per 100 person-years, adjusted hazard ratio [HR], 0.82; 95% confidence interval [CI], 0.71–0.94; p < 0.001), active (3.8 per 100 person-years; HR, 0.81; 95% CI, 0.70–0.95; p = 0.010), and highly active (2.4 per 100 person-years; HR, 0.52; 95% CI, 0.41–0.67; p < 0.001) groups compared to inactive patients. Conclusions: In older Asians with HF, increased physical activity reduced the risk of all-cause mortality. The mortality-reducing benefit started at a lower physical activity compared to the World Health Organization guideline (500–999 MET-min/week), and the risk decreased with more physical activity.
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Yu et al. (2022) conducted a cohort in Heart failure (n=8,982). High physical activity (≥1000 MET-min/week) vs. Physical inactivity was evaluated on All-cause mortality (HR 0.52, 95% CI 0.41-0.67, p=<0.001). In older adults with heart failure, high levels of physical activity (≥1000 MET-min/week) significantly reduced the risk of all-cause mortality compared to physical inactivity (HR 0.52).
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