July 9, 2007Archives of Internal Medicine
Cholesterol Fractions and Apolipoproteins as Risk Factors for Heart Disease Mortality in Older Men
Key result
A 2-SD difference in total/HDL cholesterol was strongly associated with ischemic heart disease mortality in older men (HR 1.57), whereas total cholesterol alone was not (HR 1.05).
Why the study?
Are plasma lipid levels and apolipoproteins associated with ischemic heart disease mortality in older men?
Population
5,344 older men, including 74.3% without cardiovascular disease or statin use and 25.6% with CVD or statin…
Design
Cohort
Follow-up
7 years
Authors
Discussion
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Implication
Total/HDL cholesterol ratio may better stratify IHD mortality risk than total cholesterol alone in older men; leaves open whether ratios should guide therapy.
Study Design
Type
Cohort (n=5,344)
Structured PICO
Are plasma lipid levels and apolipoproteins associated with ischemic heart disease mortality in older men?
P
Population
5,344 older men (mean age 76.9 years), including those with and without baseline cardiovascular disease or statin use, followed for 7 years.
E
Exposure
Plasma levels of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, apolipoprotein B, and apolipoprotein A(1)
O
Outcome
Ischemic heart disease mortalityhard clinical
Main Result
Hazard Ratio: 1.05
Lipid fractions and apolipoprotein ratios, rather than total cholesterol alone, are strong predictors of ischemic heart disease mortality in older men.
Cite This Study
Clarke et al. (2007) conducted a cohort in Ischemic heart disease (n=5,344). Plasma lipid levels vs. 2-SD difference in usual plasma lipid levels was evaluated on Ischemic heart disease mortality (HR 1.05). A 2-SD difference in total/HDL cholesterol was strongly associated with ischemic heart disease mortality in older men (HR 1.57), whereas total cholesterol alone was not (HR 1.05).