Key result
Left ventricular outflow tract obstruction is frequently seen in hypertrophic cardiomyopathy, affecting up to 70% of patients either at rest or with exercise.
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Highlights the high prevalence of resting and provocable left ventricular outflow tract obstruction in patients with hypertrophic cardiomyopathy.
Left ventricular outflow tract (LVOT) obstruction can be frequently seen in patients with hypertrophic cardiomyopathy (HCM). Maron et al. reported that 37% of HCM patients had LVOT obstruction with peak systolic gradient at rest ≥50mmHg [1]. Surprisingly, they also reported that an additional 33% of HCM patients had provocable LVOT obstruction with exercise, that is, a total of 70% of the patients had LVOT obstruction at rest or with exercise. Patients with obstructive HCM show mitral valve systolic anterior motion (SAM) that is determined largely by the interrelation of LVOT geometry, the size and mobility of the mitral leaflets, and the presence and distribution of fibrous thickening [2].
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Yukio Abe (2015) conducted an editorial in Hypertrophic cardiomyopathy. Left ventricular outflow tract obstruction is frequently seen in hypertrophic cardiomyopathy, affecting up to 70% of patients either at rest or with exercise.
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