August 14, 2006Echocardiography
Relationship Between Outflow Obstruction and Left Ventricular Functional Impairment in Hypertrophic Cardiomyopathy: A Doppler Echocardiographic Study
Key result
Left ventricular outflow tract obstruction in hypertrophic cardiomyopathy was associated with greater hypertrophy, higher E/Ea ratio, and lower mitral annulus velocities (P<0.0001).
Why the study?
Does LVOT obstruction correlate with left ventricular functional impairment in patients with hypertrophic cardiomyopathy?
Population
178 selected patients with hypertrophic cardiomyopathy (HCM)
Comparison
Obstructive form of HCM vs HCM without obstruction
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
LVOT obstruction linked to diastolic impairment beyond hypertrophy in HCM; hypothesis-generating, prospective studies needed.
Study Design
Type
Observational (n=178)
Structured PICO
Does LVOT obstruction correlate with left ventricular functional impairment in patients with hypertrophic cardiomyopathy?
P
Population
178 selected patients with hypertrophic cardiomyopathy evaluated by Doppler echocardiography.
E
Exposure
Obstructive form of HCM (resting peak gradient >= 30 mmHg)
C
Comparator
HCM without obstruction
O
Outcome
Left ventricular functional impairment (hypertrophy, systolic and diastolic LV functions)surrogate
Main Result
p-value: p=<0.0001
In patients with hypertrophic cardiomyopathy, LVOT obstruction is an independent determinant of left ventricular functional abnormalities beyond the effects on hypertrophy.
Cite This Study
Araujo et al. (2006) conducted an observational in Hypertrophic cardiomyopathy (HCM) (n=178). Left ventricular outflow tract (LVOT) obstruction (resting peak gradient ≥ 30 mmHg) vs. HCM without obstruction was evaluated on Left ventricular functional abnormalities and hypertrophy (p=<0.0001). Left ventricular outflow tract obstruction in hypertrophic cardiomyopathy was associated with greater hypertrophy, higher E/Ea ratio, and lower mitral annulus velocities (P<0.0001).