Key result
Amlodipine/losartan 5/50 mg significantly increased the odds of responding to antihypertensive therapy compared to amlodipine 5 mg (OR 5.33; 95% CI 1.42-25.5).
Why the study?
Does amlodipine/losartan fixed-dose combination improve blood pressure reduction compared to amlodipine monotherapy in patients with hypertension?
Does amlodipine/losartan fixed-dose combination improve blood pressure reduction compared to amlodipine monotherapy in patients with hypertension?
Odds Ratio: 5.33 (95% CI 1.42–25.5)
Fixed-dose combination of amlodipine and losartan provides superior blood pressure reduction compared to low-dose amlodipine monotherapy, supporting early combination therapy in hypertension.
Supports early amlodipine/losartan combination over monotherapy in hypertension; extends meta-analytic evidence for initial fixed-dose combinations.
Data from four clinical trials compared reductions in systolic blood pressure (SBP) and diastolic blood pressure (DBP) among patients treated with amlodipine/losartan 5/50 mg vs 5/100 mg and amlodipine/losartan 5/50 mg vs amlodipine 5 mg and 10 mg. Response rate was assessed as reduction in SBP or DBP (>20/10 mm Hg) and proportion of patients achieving SBP <140 mm Hg or DBP <90 mm Hg. Patients were grouped into quartiles based on baseline SBP and DBP. Mean SBP and DBP were reduced in amlodipine/losartan 5/50 mg (n=182) and amlodipine/losartan 5/100 mg (n=95) users across all baseline quartiles. Patients using amlodipine/losartan 5/50 mg had significantly greater SBP and DBP reductions vs amlodipine 5 mg (P=.001 and P=.02, respectively). Amlodipine/losartan 5/50 mg users had significantly greater SBP reduction vs amlodipine 10 mg (SBP P=.02; DBP P=not significant). The odds of responding to therapy were significantly greater with amlodipine/losartan 5/50 mg vs amlodipine 5 mg (odds ratio, 5.33; 95% confidence interval, 1.42-25.5) and were similar vs amlodipine 10 mg (odds ratio, 0.67; 95% confidence interval, 0.017-9.51). These results support the use of combination therapy early in the treatment of hypertension.
No takes yet. Share an insight, caveat, or question.
Unniachan et al. (2014) studied Hypertension. Amlodipine/losartan vs. Amlodipine 5 mg was evaluated on Response to therapy (reduction in SBP or DBP >20/10 mm Hg and proportion achieving SBP <140 mm Hg or DBP <90 mm Hg) (OR 5.33, 95% CI 1.42-25.5). Amlodipine/losartan 5/50 mg significantly increased the odds of responding to antihypertensive therapy compared to amlodipine 5 mg (OR 5.33; 95% CI 1.42-25.5).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: