Key result
The practical synthesis of an orally potent human renin inhibitor was achieved using a one-pot reaction to couple cyclohexylnorstatine ester with a protected histidine derivative.
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May facilitate preclinical access to renin inhibitors; leaves open clinical translation.
Harada et al. (1990) studied this question. isopropyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-{N-[(2R)-2-morpholinocarbonylmethyl-3-(1-naphthyl)propionyl]-L-histidyl}aminobutyrate was evaluated. The practical synthesis of an orally potent human renin inhibitor was achieved using a one-pot reaction to couple cyclohexylnorstatine ester with a protected histidine derivative.
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