June 1, 1988HypertensionOpen Access

A highly potent and long-acting oral inhibitor of human renin.

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Population

In vitro human renin and other enzymes; in vivo conscious, sodium-depleted marmosets and hog renin-infused…

Design

Preclinical

Follow-up

5 hours

Authors

KHKunio HiwadaGeneral / Preventive / Lipids TKTakeshi KokubuKobe Medical Center EME MurakamiChiba University

Discussion

Member takes

Implication

Supports renin inhibitor development; leaves open clinical translation in hypertension.

Structured PICO

Population

In vitro human renin and other enzymes; in vivo conscious, sodium-depleted marmosets and hog renin-infused rats

Intervention

ES 6864 (an orally active renin inhibitor) administered orally at 30 mg/kg in marmosets and at dose-related amounts in rats

Outcome

Inhibition of human renin (Ki value) and blood pressure reductionsurrogate

ES 6864 is a highly potent, orally active renin inhibitor that effectively lowers blood pressure and inhibits plasma renin activity in preclinical models, demonstrating potential for clinical development.

Cite This Study

Hiwada et al. (1988) studied this question.

synapsesocial.com/papers/6a8a5c3fe0083a7c2c436d76 https://doi.org/10.1161/01.hyp.11.6.708

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A highly potent and long-acting oral inhibitor of human renin.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A highly potent and long-acting oral inhibitor of human renin.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider