Why the study?
Does U-71038 reduce blood pressure and plasma renin activity in animal models?
Population
Anesthetized, ganglion-blocked rats infused with hog renin and conscious, sodium-depleted monkeys
Design
Preclinical
Follow-up
5 hours
Authors
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Supports oral renin inhibition feasibility in primates; leaves open human translation and clinical utility.
Does U-71038 reduce blood pressure and plasma renin activity in animal models?
The study demonstrates that an orally effective renin inhibitor with a long duration of action is a feasible pharmacological entity.
Pals et al. (1986) studied this question.
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