Key result
Cardiovascular magnetic resonance demonstrated a higher sensitivity (98.4%) for diagnosing any cardiac amyloidosis compared to bone scintigraphy (85.4%).
Why the study?
Comparative imaging data based on concurrent CMR and bone scintigraphy in the same patients with biopsy-proven cardiac amyloidosis were rare.
Does cardiovascular magnetic resonance provide higher diagnostic sensitivity than bone scintigraphy in patients with suspected cardiac amyloidosis?
Observational (n=123)
No
Does cardiovascular magnetic resonance provide higher diagnostic sensitivity than bone scintigraphy in patients with suspected cardiac amyloidosis?
Absolute Event Rate: 98.4% vs 85.4%
CMR provides superior diagnostic sensitivity compared to bone scintigraphy for detecting cardiac amyloidosis across different subtypes, suggesting no incremental value of bone scintigraphy if CMR is unequivocally positive.
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CMR may enhance sensitivity for cardiac amyloidosis over scintigraphy; leaves open whether it should replace combined testing in practice.
Obergassel et al. (2025) conducted an observational in Suspected cardiac amyloidosis (n=123). Cardiovascular magnetic resonance (CMR) vs. Bone scintigraphy was evaluated on Sensitivity for the diagnosis of any cardiac amyloidosis. Cardiovascular magnetic resonance demonstrated a higher sensitivity (98.4%) for diagnosing any cardiac amyloidosis compared to bone scintigraphy (85.4%).
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