Key result
In a porcine model, 40% bleeding resulted in a higher mean arterial pressure compared to 60% bleeding (110 vs 89 mmHg) and did not cause irreversible shock or mortality.
Absolute Event Rate: 110% vs 89%
A nonlethal porcine model combining 40% hemorrhage and aortic cross-clamping was successfully developed to study the systemic inflammatory response during abdominal aortic surgery.
Enables nonlethal porcine modeling of hemorrhage in aortic surgery; leaves open translation to human inflammatory responses.
The aim of this study was to design an aggressive nonlethal animal model that would simulate surgical treatment of the abdominal aorta with a view to studying the systemic inflammatory response. Fourteen pigs were subjected to two sequential experiments. Experiment A was performed to determine the response to two degrees of hemorrhage: (A1) 40% bleeding; and (A2) 60% bleeding over 15 minutes followed by midline laparotomy and aortic dissection. Experiment B included two methods of aortic repair: (B1) aortic resection and replacement with a prosthesis; and (B2) aortic bypass without aortic resection. In the latter two groups, suprarenal aortic cross-clamping was placed for 30 minutes after a 40% hemorrhage. We analyzed various inflammatory markers and mortality. The 40% bleeding (vs. 60%) elicited a smaller decrease in mean arterial pressure (110 +/- 6 vs. 89 +/- 9 mmHg) but did not cause irreversible shock or mortality. After the 40% hemorrhage, the B1 aortic repair caused two cases of paraplegia. We have developed a model to study the combined effect of bleeding and aortic cross-clamping.
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Lozano et al. (2008) studied Emergency surgery of the abdominal aorta (porcine model) (n=14). 40% bleeding vs. 60% bleeding was evaluated on Mean arterial pressure. In a porcine model, 40% bleeding resulted in a higher mean arterial pressure compared to 60% bleeding (110 vs 89 mmHg) and did not cause irreversible shock or mortality.
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