Key result
Side-clamping without pentobarbital enables viable swine aortic dissection models by preventing fatal heart failure.
Why the study?
The use of mongrel dogs for experimental aortic dissection models was recently restricted, necessitating development of a swine model.
Does avoiding pentobarbital anesthesia and cross-clamping allow for successful creation of an aortic dissection model in swine?
Does avoiding pentobarbital anesthesia and cross-clamping allow for successful creation of an aortic dissection model in swine?
A swine model of thoracic aortic dissection can be successfully created if pentobarbital anesthesia and cross-clamping of the descending aorta are avoided.
Answers are grounded in this paper and cite their sources.
May enable refined swine aortic dissection models; leaves open clinical translation pending validation.
The use of mongrel dogs for experimental purposes was recently restricted and this report presents the experience of creating an aortic dissection model in swine. All the swine in group 1 were anesthetized without pentobarbital and the descending aorta was side-clamped during the creation of the aortic dissection. The false lumen of the completed dissection was patent in the long term despite not having the anchoring suture that the previous canine model required to stabilize the opening of the entry tear. All the swine anesthetized with pentobarbital (ie, group 2) died of heart failure either during cross-clamping of the descending aorta or postoperative aortography. In conclusion, creation of a thoracic aortic dissection is possible in swine, but cross-clamping of the thoracic descending aorta and pentobarbital anesthesia should be avoided.
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Fujii et al. (2000) studied Aortic dissection. Anesthesia without pentobarbital and side-clamping of the descending aorta vs. Pentobarbital anesthesia and cross-clamping was evaluated on Survival and patency of the false lumen. Creation of a thoracic aortic dissection model is possible in swine using side-clamping without pentobarbital, whereas all swine receiving pentobarbital died of heart failure.
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