Key result
Long-term alcohol consumption was associated with a 1.88-fold increase in stromal sclerotic changes and a 1.23-fold increase in fatty degenerated cardiomyocytes compared to ischemic heart disease.
Why the study?
Alcohol abuse negatively affects cardiovascular functioning, motivating an evaluation of the severity of pathomorphological changes in the hearts of deceased patients with alcoholism.
Does long-term alcohol consumption cause specific pathomorphological changes in the heart compared to ischemic heart disease and hypertension?
Population
35 deceased alcoholic patients aged 38-60 years and 15 deceased comparison patients
Comparison
Deceased alcoholic patients vs deceased patients with IHD and HD
Design
Histo-morphometric comparative autopsy study
Authors
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Autopsy data on alcoholic hearts support hypothesis generation; leaves open prospective links to clinical progression or reversibility.
Observational (n=50)
No
Does long-term alcohol consumption cause specific pathomorphological changes in the heart compared to ischemic heart disease and hypertension?
Effect estimate: 1.88 times higher
Absolute Event Rate: 16.04% vs 8.53%
p-value: p=<0.05
Long-term alcohol consumption leads to specific pathomorphological changes in the heart, including increased fatty degeneration and stromal sclerosis, which form the morphological substrate of alcoholic cardiomyopathy.
Тертышный et al. (2020) conducted an observational in Alcoholism / Alcoholic cardiomyopathy (n=50). Long-term alcohol consumption vs. Ischemic heart disease (IHD) and hypertension disease (HD) was evaluated on Area of sclerotic changes in stroma compared to IHD (1.88 times higher, p=<0.05). Long-term alcohol consumption was associated with a 1.88-fold increase in stromal sclerotic changes and a 1.23-fold increase in fatty degenerated cardiomyocytes compared to ischemic heart disease.
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