Key result
Autoimmune serum from a scleroderma patient identified a 94 kDa nucleolar protein associated with ribosomal RNA transcription sites and preribosome assembly.
Population
Cells of 3 different mammalian species and autoimmune serum (ScBr) from scleroderma patients
Design
Preclinical
Authors
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Hypothesis-generating for nucleolar protein function in scleroderma; leaves open validation of its role in ribosomal biogenesis.
The 94 kDa nucleolar protein identified by scleroderma autoimmune serum likely plays a role in preribosome assembly.
Hernandez‐Verdun et al. (1988) studied Scleroderma. Autoimmune serum (ScBr) was evaluated on Localization and characterization of the 94 kDa nucleolar protein. Autoimmune serum from a scleroderma patient identified a 94 kDa nucleolar protein associated with ribosomal RNA transcription sites and preribosome assembly.
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