Key result
Hypertension in patients with symptomatic peripheral artery disease was associated with higher arterial stiffness (ß=2.59±0.76 m/s, p=0.003), especially when blood pressure was uncontrolled.
Why the study?
The impact of hypertension on cardiovascular health and the factors associated with uncontrolled hypertension in patients with symptomatic peripheral artery disease needed examination.
Does hypertension increase arterial stiffness and alter cardiac autonomic modulation in patients with symptomatic peripheral artery disease?
Cross-Sectional (n=251)
Does hypertension increase arterial stiffness and alter cardiac autonomic modulation in patients with symptomatic peripheral artery disease?
Hypertension, particularly when uncontrolled, is associated with increased arterial stiffness in patients with symptomatic peripheral artery disease.
Hypertension was associated with greater arterial stiffness in symptomatic PAD; leaves open whether tighter BP control improves outcomes.
OBJECTIVE: To examine the impact of hypertension on cardiovascular health in patients with symptomatic peripheral artery disease and to identify factors associated with uncontrolled hypertension. METHODS: A cross-sectional study including 251 patients with symptomatic peripheral artery disease (63.9% males, mean age 67±10 years). Following hypertension diagnosis, blood pressure was measured to determine control of hypertension. Arterial stiffness (carotid-femoral pulse wave velocity) and cardiac autonomic modulation (sympathovagal balance) were assessed. RESULTS: Hypertension was associated with higher carotid-femoral pulse wave velocity, regardless of sex, age, ankle-brachial index, body mass index, walking capacity, heart rate, or comorbidities (ß=2.59±0.76m/s, b=0.318, p=0.003). Patients with systolic blood pressure ≥120mmHg had higher carotid-femoral pulse wave velocity values than normotensive individuals, and hypertensive patients with systolic blood pressure of ≤119mmHg (normotensive: 7.6±2.4m/s=≤119mmHg: 8.1±2.2m/s 120-129mmHg:9.8±2.6m/s=≥130mmHg: 9.9±2.9m/s, p<0.005). Sympathovagal balance was not associated with hypertension (p>0.05). CONCLUSION: Hypertensive patients with symptomatic peripheral artery disease have increased arterial stiffness. Arterial stiffness is even greater in patients with uncontrolled high blood pressure.
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Farah et al. (2021) conducted a cross-sectional in symptomatic peripheral artery disease (n=251). Hypertension vs. Normotensive individuals was evaluated on Arterial stiffness (carotid-femoral pulse wave velocity) (ß=2.59±0.76m/s, p=0.003). Hypertension in patients with symptomatic peripheral artery disease was associated with higher arterial stiffness (ß=2.59±0.76 m/s, p=0.003), especially when blood pressure was uncontrolled.
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