Key result
Combined pyridostigmine and stress greatly increased pulse interval standard deviation (11.0 +/- 1.4 ms) compared with stress (5.0 +/- 0.9 ms) or pyridostigmine (7.5 +/- 0.9 ms) alone in mice.
Why the study?
Does combined stress and cholinesterase inhibition alter cardiovascular responses in mice?
Population
Male C57BL/6J mice with arterial catheters
Comparison
Combined pyridostigmine (10 mg.kg.day) and… vs Intermittent shaker stress alone, or…
Design
Preclinical
Follow-up
3 days
Authors
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Remains hypothesis-generating in mice; leaves open any clinical relevance of combined stress and cholinesterase inhibition.
Does combined stress and cholinesterase inhibition alter cardiovascular responses in mice?
Absolute Event Rate: 11% vs 5%
Combined mild stress and cholinesterase inhibition with pyridostigmine accentuates low-frequency variability in pulse interval and increases baroreflex sensitivity in mice.
Joaquim et al. (2004) studied this question. Combined pyridostigmine and stress vs. Intermittent shaker stress alone or pyridostigmine alone was evaluated on Pulse interval standard deviation. Combined pyridostigmine and stress greatly increased pulse interval standard deviation (11.0 +/- 1.4 ms) compared with stress (5.0 +/- 0.9 ms) or pyridostigmine (7.5 +/- 0.9 ms) alone in mice.
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