Key result
Intermittent shaker stress in mice produced greater increases in mean arterial pressure during the light (nonactive) phase compared to the dark phase (+24% vs +11% on stress day 3).
Population
Male C57BL6 mice with carotid arterial catheters
Comparison
7 days of intermittent shaker stress delivered… vs Basal and recovery periods; dark period vs light…
Design
Preclinical
Follow-up
7 days
Authors
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Hypothesis-generating for circadian stress effects on BP; does not support practice changes in humans.
Absolute Event Rate: 24% vs 11%
Stress exposure during the nonactive circadian phase produces greater pressor reactivity in mice, indicating a potential mechanism for increased cardiovascular risk.
Bernátová et al. (2002) studied Chronic stress exposure. Intermittent shaker stress vs. Dark period (active phase) / Basal periods was evaluated on Pressor responses (increase in mean arterial pressure) on stress day 3. Intermittent shaker stress in mice produced greater increases in mean arterial pressure during the light (nonactive) phase compared to the dark phase (+24% vs +11% on stress day 3).
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