Key result
A 44-year-old female patient with anxiety disorder spontaneously developed periorbital purpura during treatment with sertraline.
Why the study?
Does sertraline cause spontaneous bleeding such as periorbital purpura in patients with anxiety disorder?
Case Report (n=1)
Does sertraline cause spontaneous bleeding such as periorbital purpura in patients with anxiety disorder?
Sertraline use may be associated with spontaneous bleeding events such as periorbital purpura, highlighting the need for caution, especially when used with anti-aggregants.
May heighten bleeding vigilance with SSRI plus anti-aggregant use; single case leaves open interaction magnitude and causality.
OBJECTIVE: The incidence of mild to severe levels of spontaneous bleeding due to the usage of selective serotonin reuptake inhibitors (SSRIs) is relatively low. Although the exact mechanism is not known, it is thought that inhibition of the serotonin transporter together with a decrease in platelet serotonin could be responsible for the bleeding. Therefore, the use of SSRIs in conjunction with anti-aggregants may predispose to or exacerbate the risk of bleeding. In this case report, we describe a 44-year-old female patient with a diagnosis of anxiety disorder who spontaneously developed periorbital purpura during treatment with sertraline. CONCLUSION: Abnormal bleeding after treatment with an SSRI should be kept in mind, and alternative non-SSRI drugs of choice in such cases would be more appropriate. More extensive and comprehensive studies focusing on hemostasis and bleeding disorders are needed for SSRIs such as sertraline.
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Kayhan et al. (2015) conducted a case report in Anxiety disorder (n=1). Sertraline was evaluated on Spontaneous periorbital purpura. A 44-year-old female patient with anxiety disorder spontaneously developed periorbital purpura during treatment with sertraline.
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