Why the study?
Does the prevalence of high frequency flux waves measured by laser Doppler differ between healthy controls and patients with peripheral arterial occlusive disease, and does it change after angioplasty?
Observational
Does the prevalence of high frequency flux waves measured by laser Doppler differ between healthy controls and patients with peripheral arterial occlusive disease, and does it change after angioplasty?
High frequency flux waves measured by laser Doppler are increased in peripheral ischemia and decrease following successful angioplasty, suggesting utility as a marker of ischemia.
May support laser Doppler flux waves as ischemia marker; hypothesis-generating, needs prospective validation.
Analysis of flux motion by the laser Doppler technique in the forefoot of healthy controls and patients with peripheral arterial occlusive disease was performed by establishing computerized frequency histograms. It was found that the low frequency components (1-10 cycles/min) are caused by local vasomotion. The prevalence of high frequency flux waves (15-25 cycles/min) is significantly increased in peripheral ischemia compared to normal conditions. After successful reopening of large arteries by angioplasty the prevalence decreases (p less than 0.001). Preliminary results indicate that these high frequency rhythmic fluctuations might by induced by respiration.
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Bollinger et al. (2008) conducted an observational in Peripheral arterial occlusive disease. Peripheral arterial occlusive disease and angioplasty vs. Healthy controls and pre-angioplasty baseline was evaluated on Prevalence of high frequency flux waves (15-25 cycles/min) (p=<0.001).
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