Key result
Heat shock protein 70 protects cardiac SERCA2a against peroxynitrite-induced inactivation via reduced carbonyl accumulation.
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Supports targeting HSP70 to preserve SERCA2a function; extends basic mechanisms but does not yet inform clinical practice.
exposure and that this protection is associated with reduced SERCA2a carbonyl accumulation.
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Vigna et al. (2026) studied this question. Heat shock protein 70 protects against peroxynitrite-induced inactivation of cardiac SERCA2a, an effect associated with reduced SERCA2a carbonyl accumulation.
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