Diffuse alveolar haemorrhage as a rare complication of high-dose methotrexate toxicity

Q: What does this research mean for the field?

High-dose methotrexate toxicity can rarely manifest as diffuse alveolar haemorrhage, potentially exacerbated by impaired drug clearance due to acute kidney injury. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Adeline Ngo Su-Yin; Daryl Tan Chen Lung

doi:10.1080/15563650.2026.2718885

September 2, 2026Clinical Toxicology

Diffuse alveolar haemorrhage as a rare complication of high-dose methotrexate toxicity

View at Publisher

Ask AI

Bookmark

Share

Key Points

To describe diffuse alveolar haemorrhage as a severe pulmonary manifestation linked to high-dose methotrexate toxicity exacerbated by acute kidney injury.
Clinical evaluation and diagnostic workup of high-dose methotrexate toxicity in a clinical patient setting.
Assessment of renal function, systemic drug clearance rates, and pulmonary disease progression.
Acute kidney injury significantly impaired methotrexate elimination, escalating systemic drug exposure.
Diffuse alveolar haemorrhage developed as a rare and severe pulmonary complication directly associated with drug accumulation.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Case report demonstrates diffuse alveolar haemorrhage following high-dose methotrexate therapy, highlighting the role of impaired clearance in severe pulmonary toxicity.

Abstract

Dear Editor,High-dose methotrexate can cause severe systemic toxicity, most critically acute kidney injury (AKI), which impairs drug clearance and amplifies end-organ exposure [1]. Pulmonary toxici...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Su-Yin et al. (2026) studied this question.

synapsesocial.com/papers/6a9a85d25d9e33f25c63137d https://doi.org/10.1080/15563650.2026.2718885

View at Publisher

Ask AI

Bookmark

Share

Diffuse alveolar haemorrhage as a rare complication of high-dose methotrexate toxicity

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Diffuse alveolar haemorrhage as a rare complication of high-dose methotrexate toxicity

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading