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Systematic review evaluates the prognostic significance of PTHrP subcellular localization across solid malignancies, highlighting its variable role in tumor behavior and patient outcomes.
Parathyroid hormone-related protein (PTHrP) has important roles in calcium regulation and tumour biology. Emerging evidence suggests that its effects on tumour behaviour may depend not only on the level of PTHrP expression but also on its subcellular localisation.Nuclear and cytoplasmic PTHrP localisation have been associated with processes such as cell proliferation, apoptosis, invasion and metastasis. However, their prognostic significance across solid malignancies remains unclear, with inconsistent findings between studies.This systematic review aims to synthesise the available evidence on the prognostic significance of PTHrP subcellular localisation in solid malignancies. Where appropriate and sufficient comparable data are available, a meta-analysis will also be undertaken.
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Shetty et al. (2026) studied this question.
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