Key result
Oxidative stress leads to platelet activation and aggregation, presenting a challenge for acetylsalicylic acid treatment in acute coronary syndrome.
Cardiovascular diseases (CVD) are the leading cause of death in the world, with coronary heart disease being the main etiology, accounting in 2016 for 31% of global deaths. 1 Myocardial infarction (MI) is usually due to changes in the arterial wall or thrombotic occlusion of a coronary vessel caused by the rupture of a vulnerable plaque. Instability in the atherosclerotic plaque is the result of local and systemic oxidative stress, thus leading to platelet activation and formation of aggregates in the circulation. The major function of platelets is as part of the homeostatic mechanism, halting blood loss after tissue trauma, but in oxidative conditions, they are associated with various CVD such as hypertension, heart failure, stroke, diabetes and atherosclerosis.
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Filho et al. (2019) conducted a review in Acute Coronary Syndrome. Acetylsalicylic Acid was evaluated. Oxidative stress leads to platelet activation and aggregation, presenting a challenge for acetylsalicylic acid treatment in acute coronary syndrome.
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