Key result
Nonsteroidal antiinflammatory drug (NSAID) treatment was associated with the development of segmental ischemic colitis in two cases without other etiologic factors.
Why the study?
Can NSAID treatment induce segmental ischemic colitis?
Case Report (n=2)
Can NSAID treatment induce segmental ischemic colitis?
Ischemia should be considered a possible mechanism of NSAID-associated colitis, which may occur without severe cardiovascular disease.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for ischemia as NSAID colitis mechanism without cardiovascular disease; prospective studies needed to confirm causality.
We have seen two cases of a segmental ischemic colitis develop during nonsteroidal antiinflammatory drug (NSAID) treatment. No other possible etiologic factors were shown. The short-term clinical course and the follow-up were uneventful. NSAIDs have been reported to cause different lesions in the large bowel, either by worsening preexisting colonic diseases or by inducing a primary pathology. We suggest that ischemia should be considered a possible mechanism of NSAID-associated colitis. Such ischemic colitis, not triggered by severe cardiovascular disease or operation, may be related to NSAIDs more often than currently recognized.
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Carratùu et al. (1993) conducted a case report in Segmental ischemic colitis (n=2). Nonsteroidal antiinflammatory drugs (NSAIDs) was evaluated on Development of segmental ischemic colitis. Nonsteroidal antiinflammatory drug (NSAID) treatment was associated with the development of segmental ischemic colitis in two cases without other etiologic factors.
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