Answers are grounded in this paper and cite their sources.
Upon hospital admission a patient was found to have severe anemia and a strongly positive direct antiglobulin test (DAT). The patient was taking probenecid periodically for gout. An antibody was detected in the patient's serum that only reacted with red blood cells (RBCs) when probenecid was added. Eluates from the patient's RBCs, with and without the presence of drug, were nonreactive. Upon the discontinuation of probenecid, the patient's hemoglobin level improved steadily. We believe this to be the first reported case of immune hemolytic anemia associated with probenecid.
No takes yet. Share an insight, caveat, or question.
Sosler et al. (1985) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: