Key result
Significant weight loss following bariatric surgery in morbidly obese women significantly increased circulating MMP-7 levels, though not reaching the levels of lean healthy women.
Why the study?
Does significant weight loss following bariatric surgery alter circulating MMP and TIMP levels in morbidly obese women?
Cohort (n=36)
Does significant weight loss following bariatric surgery alter circulating MMP and TIMP levels in morbidly obese women?
Significant weight loss from bariatric surgery partially restores reduced MMP-7 levels in morbidly obese women, suggesting reversible adipose tissue reorganization.
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Bariatric weight loss may alter matrix remodeling markers in obese women; leaves open links to cardiovascular outcomes.
Ress et al. (2010) conducted a cohort in Morbid obesity (n=36). Bariatric surgery and significant weight loss vs. Baseline (before surgery) and lean healthy women was evaluated on Circulating MMP-2, -3, -7 and TIMP-1, -2 and -4 serum levels. Significant weight loss following bariatric surgery in morbidly obese women significantly increased circulating MMP-7 levels, though not reaching the levels of lean healthy women.
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