Key result
Obesity was associated with significantly elevated plasma levels of MMP-1, MMP-2, TIMP-1, and TIMP-2, which correlated with body mass index, waist circumference, and endothelial dysfunction.
Why the study?
The association between MMPs, TIMPs, and obesity as well as obesity-related disease including metabolic syndrome was not fully explored.
Cross-Sectional (n=479)
No
Absolute Event Rate: 2.5% vs 1.18%
p-value: p=0.015
Plasma levels of specific MMPs and TIMPs correlate with obesity, blood pressure, and endothelial dysfunction, suggesting their potential utility as biomarkers in obesity-related cardiovascular diseases.
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May support MMP/TIMP profiling for future risk stratification in obesity; leaves open causal roles and clinical utility.
Boumiza et al. (2021) conducted a cross-sectional in Obesity and metabolic syndrome (n=479). Obesity vs. Non-obese healthy individuals was evaluated on Plasma MMP-1 levels (ng/ml) (p=0.015). Obesity was associated with significantly elevated plasma levels of MMP-1, MMP-2, TIMP-1, and TIMP-2, which correlated with body mass index, waist circumference, and endothelial dysfunction.
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