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A highly enantioselective, organocatalytic Michael addition reaction of unmodified ketones with chalcones has been developed for the first time. The process, catalyzed by (S)‐N‐(pyrrolidin‐2‐ylmethyl)‐trifluoromethanesulfonamide, affords 1,5‐diketones in high yields (73–89%) and with high degrees of enantio‐ and diastereoselectivity (86–97% ee, >30 : 1 dr).
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Wang et al. (2006) studied this question.
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