Key result
Ribavirin mutagenesis accelerated the occurrence of AU-rich mutant clouds during early viral replication rounds, revealing a deep, mutationally biased portion of sequence space in FMDV quasispecies.
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May inform antiviral mutagenesis strategies in RNA viruses; leaves open clinical translation or extension beyond FMDV quasispecies.
Perales et al. (2011) studied Foot-and-Mouth Disease Virus (FMDV). Ribavirin vs. Absence of ribavirin was evaluated on Occurrence of AU-rich mutant clouds and ribavirin resistance mutations. Ribavirin mutagenesis accelerated the occurrence of AU-rich mutant clouds during early viral replication rounds, revealing a deep, mutationally biased portion of sequence space in FMDV quasispecies.
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