Why the study?
Does the combination of a mutagenic agent and antiviral inhibitors prevent extinction-escape mutants in foot-and-mouth disease virus?
Does the combination of a mutagenic agent and antiviral inhibitors prevent extinction-escape mutants in foot-and-mouth disease virus?
The combination of a mutagenic agent with antiviral inhibitors effectively prevents the emergence of escape mutants and drives foot-and-mouth disease virus to extinction.
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Supports mutagenic-antiviral combos to block FMDV escape; leaves open translation beyond animal models.
Pariente et al. (2003) studied this question.
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