Key result
Cotransfection of mutated, preextinction foot-and-mouth disease virus RNA with standard RNA in BHK-21 cells interfered with and delayed viral production for up to 30 hours.
Mutated preextinction viral RNA can interfere with viral production, suggesting an advantage of lethal mutagenesis over simple inhibition in antiviral treatments.
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Delays viral production in cell culture; leaves open whether lethal mutagenesis confers therapeutic advantage for foot-and-mouth disease virus.
González-López et al. (2004) studied Foot-and-mouth disease virus (FMDV) infection (in vitro). Mutated, preextinction foot-and-mouth disease virus (FMDV) RNA vs. Unrelated RNAs or nonmutated, defective FMDV RNA was evaluated on Viral production interference and delay. Cotransfection of mutated, preextinction foot-and-mouth disease virus RNA with standard RNA in BHK-21 cells interfered with and delayed viral production for up to 30 hours.
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